Kendra Wilkinson, Khloe Kardashian & More Who've Weighed In on Ozempic
One hot topic everyone in Hollywood still seems to be talking about that isn't Traylor? Oh-oh-oh Ozempic.
Originally marketed for treating Type 2 diabetes, Ozempic—perhaps the most popular of the injectable medications called semaglutide that was FDA-approved in 2017—has become the weight loss trend. And, like many wellness fads in the past, it's sparking debate, especially after the FDA logged a reported shortage of the drug in 2022 due to an increase in demand.
As first reported by Variety, celebrities began taking the insulin drug (and then others like Mounjaro and Wegovy) as a way to lose weight quickly, though many stars suspected of using it have been quick to deny the rumors.
Lizzo, for instance, addressed her weight loss on social media, by writing, "When you finally get ozempic allegations after 5 months of weight training and calorie deficit."
And Kelly Clarkson shared that Ozempic is not her medication of choice. Though, as she said on a May 2024 episode of The Kelly Clarkson Show, she is taking "something that aids in helping break down the sugar—obviously my body doesn't do it right."
Amy Schumer, meanwhile, says she tried Ozempic a couple years ago ("I was one of those people that felt so sick and couldn't play with my son," she admitted) and called out those in Hollywood who won't admit that they've done the same.
Not that there aren't some stars who have shared their experiences with the drug, including Chelsea Handler, Tracy Morgan, Kendra Wilkinson and Meghan Trainor, who recently revealed both she and husband Daryl Sabara are taking a low dose of Mounjaro.
But other celebs—like Khloe Kardashian and The Real Housewives of Beverly Hills star Kyle Richards—have vehemently denied assumptions that they are on Ozempic.
Though Khloe, for one, isn't here to judge.
“Even if people get surgery or [get on] the Ozempic craze, I’m like, ‘Who cares!’” the 40-year-old told Bustle in an interview published Dec. 3. “As long as people feel good about themselves, who am I to judge? I think it’s ridiculous, the judgment on that.” Her biggest gripe, she added, “I’m just mad [Ozempic] wasn’t around 10 years ago.”
A rep for the pharmaceutical company Novo Nordisk, which makes Ozempic, previously told E! News in a statement that Ozempic is "not approved for chronic weight management." The organization said that Ozempic is intended to treat type 2 diabetes, improve blood sugar and minimize risks of major cardiovascular events for adults with the condition.
Here are the stars who have sounded off on the Ozempic craze in Hollywood:
The couple that pees together also pokes together. Following the 2021 birth of eldest son Riley, singer Meghan Trainor and her actor husband Daryl Sabara did the 75 Hard challenge, "and, man, did we crush,” Meghan detailed during the April 9 episode of the couple’s Workin’ On It podcast. “Then, we heard more and more of our friends—and even our doctors—were on Mounjaro and Ozempic.”
They each opted to get on the lowest dose possible of Monjaro, combining the shots with exercise and balanced meals. “Daryl and I both do everything together," the "All About That Bass" singer explained. "And we started that journey.”
Former Girls Next Door star Kendra Wilkinson gave one unnamed weight loss injectable a shot. Exactly one, to be precise. “I started the weight loss shots,” she wrote on her Instagram Stories in April 2025. “Only did one. Nevermind. Throwing away!!”
Ultimately, said the Playboy model, she wasn't interested in hopping into any potential health risks. “Heard too many horror stories around me,” explained the mom of two. “People end up in ER. Surgeries. No thanks.”
The Golden Globes host fiercly defended the use of Ozempic in March 2025, calling for people to be more open about using the medication.
“I love it. I’m like, ‘Do it,’” she said on The Tonight Show Starring Jimmy Fallon. “I have no judgment. If you want to do Ozempic, hell yeah, girl.”
She added, “I want people to feel more comfortable talking about doing it, because I feel like there's this shame,” she continued. “The shame is only from thin people who want you to stay fat. That's really where it's coming from. They're so mad that you're getting thin now, because that's all they have, right? You’re dynamic, you have a good personality, and they're so mad.”
In December 2024, the model said she had once taken Ozempic but stopped after she started competing on Dancing With the Stars the previous fall.
"I took, like, a little bit when it first came out, and everyone was doing it," Nader told Us Weekly. "It made me really nauseous. I liked it—I am not going to lie—and when I went on Dancing with the Stars, I could not do both."
Brooks said she "lost a little bit of the motivation and the strength to work out" by taking the medication. "It was one or the other," she said, "and I picked dancing. I put the shot away."
Dog the Bounty Hunter's daughter shared Nov. 1 that she had lost 58 pounds in 10 months thanks to a change in diet and the use of the weight loss medication Tirzepatide, adding, "I am able to look at myself in the mirror and feel so proud of where I've gotten."
But before finding the solution that works for her, she had a rough go with Ozempic. "I hated it," she revealed to E! News. "I could not eat without feeling nauseous. I could not eat at all, sometimes. My body did not like it."
The Real Housewives of New York City star shot down speculation about her glow-up between seasons 14 and 15.
“I think that when you’re in reality TV, it’s so natural to be like, ‘Oh, she got plastic surgery or she did this or she’s on Ozempic,’” she told Us Weekly in October 2024. “I actually f--king hate Ozempic. I would never put needles in myself.”
After several fans speculated on social media that Lizzo used Ozempic to lose weight, following a post she shared in which she showcased a slimmer figure, the Grammy winner posted this video, set to a viral TikTok sound bite of Christoph Waltz's character saying, "It's like a reward" from Django Unchained.
Kate Moss' little sis revealed why getting on Ozempic was "the worst decision I ever made," during a September 2024 episode of her Dream On podcast.
After taking a dosage meant for those roughly 220 pounds or more, the model was struggling to keep any food or water down and landed in the emergency room.
“I literally had a seizure from how dehydrated I was, which honestly was the scariest thing that’s ever happened to me in my life,” she admitted. “My friend had to hold my feet down. It was so scary, the whole situation. My face was clenching up, my whole body was tense.”
The Jon & Kate Plus 8 alum told Page Six in April 2024 that he lost 32 pounds in two months after taking injections of semaglutide, the generic form of Ozempic.
"You know what's annoying?" he said. "The regret of not starting it 10 years ago."
The Pioneer Woman star shared on her blog in March 2024 that her 50-pound weight loss in 2022 was not due to taking Ozempic or similar medications.
She added, "But you'll never hear a second of judgment from me about people who choose that direction!"
In August 2023, the 30 Rock alum said on Today With Hoda and Jenna that he lost weight on Ozempic because it supressed his appetite.
In March 2024, his health journey appeared to take a surprising turn. "I've learned to out-eat Ozempic," he said on The Tonight Show Starring Jimmy Fallon. "I gained 40 pounds."
Later that month, he clarified to E! News that he was joking, adding, "Ozempic did great by me and I was glad to use it."
The Real Housewives of Dubai star opened up about using Ozempic after going through a "midlife crisis" at 45.
"After 40, we all know it's very, very hard to lose weight," she said in the May 22 episode of her podcast Uncut & Uncensored With Caroline Stanbury. "But I met so many 40-year-old women going, 'How have you done it?' And I don't want to lie to you, I used Ozempic, which I think is one of the best tools if you're able to use it."
The Real Housewives of New Jersey star declared "I am not on Ozempic" during a July 2024 Watch What Happens Live interview before hilariously adding, "I'm on Mounjaro, okay. I'm sorry! I love being this weight, I love it! I have so much energy if you couldn't tell."
The Real Housewives of Atlanta alum revealed her failed attempt to lose weight with the injectable medication.
"It didn't curb my appetite. I know some people are like, ‘Oh, I can't eat.' Not me! I was eating appetizers, a regular meal and dessert, okay? It didn't stop anything for me," she shared in June 2024. "When you see it worked for other people and it doesn't work for you, it makes you depressed. Realistically, it makes you feel like, ‘What is wrong with me? Why is it not working for me?'"
“I can’t speak medically about it, but I do know that there’s so much information about what’s working and what’s not,” she shared during part of an interview with Fox News Digital. “I think that Ozempic has some great benefits, and I also think it has some dangers.”
The Beverly Hills, 90210 tried the drug to help her slim down after giving birth to her son Beau in 2017.
"I tried Ozempic and it didn't work for me," she shared in an April 2024 episode of her misSPELLING podcast, "so I went on Mounjaro, which did do the trick and I did lose weight."
"I think it's very important we understand certain medications are made for certain people," the actress told E! News' Francesca Amiker, "and to not take that away just for glamazon purposes."
Raven continued, "Do what you gotta do, just make sure you save the medication for the people who actually need it."
The Talk U.K. host revealed in September 2023 that she shed 42 pounds after using Ozempic earlier in the year.
"Whatever you choose is up to you," she exclusively told E! News. "It's not a dirty little secret when you've taken something to help you lose weight, which is perfectly fine."
She added, "We don't have to bulls--t."
Sharon's daughter has also weighed in on the Ozempic trend.
"I think it's amazing," the Fashion Police alum told E! News in January 2024. "There are a million ways to lose weight, why not do it through something that isn't as boring as working out?"
The Titanic star, who was once a target for tabloids when it came to her weight, shared what she thought about the weight loss trend.
"I actually don't know what Ozempic is," Kate admitted to The New York Times Magazine in an interview published in March 2024. "All I know is that it's some pill that people are taking or something like that."
"Oh, my God," Kate remarked after learning about the injectable. "This sounds terrible."
The Hills star revealed in December 2023 that she'd recently lost 22 pounds—without taking Ozempic. "There's no shortcuts in life. And if you're taking that shortcut, I don't know," she told Page Six of other celebrities using the drug. "I don't want to name names or get into it, it's just nothing I would ever do."
Heidi noted, "I want something that is sustainable. I want something that does also require hard work."
The Trainwreck star did not hold back when she called out celebrities for not being honest about using Ozempic as a weight loss tool during her June 8, 2023 appearance on Watch What Happens Live.
"Everyone and their mom is gonna try it. Everyone has been lying saying, 'Oh, smaller portions,'" she told Andy Cohen, who has also publicly weighed in on the Ozempic craze multiple times. "Like, shut the f--k up. You are on Ozempic or one of those things, or you got work done. Just stop."
Schumer, who has been open about her past medical procedures, added, "Be real with people. When I got lipo, I said I got lipo."
She admitted to becoming "immediately invested" in Ozempic in 2022, but explained that it was not "livable" for her to take the Type 2 diabetes drug as it hindered her ability to spend time with her son Gene.
"I was one of those people that felt so sick and couldn't play with my son," Schumer recalled. "I was so skinny, and he's throwing a ball at me and [I couldn't]."
"People have a mixed feeling about interventions like this," Dr. Drew exclusively told E! News at Fox's Special Forces: World's Toughest Test season two event in Los Angeles on Sept. 12, 2023. "They're tantalized by it, but on the other hand, they have this weird judgment."
He continued, "If we have a medication that can be helpful, by all means, people should be encouraged to think about it."
Forget winter, a hot take is coming.
The Game of Thrones alum was not shy when it came to sharing her opinion about Ozempic and its advertisements.
In an April 5, 2023 Instagram Story, the actress reposted a tweet from writer Sophie Vershbow that read, "The Ozempic ads plastered across the Times Square subway station can f--k all the way off." One ad featured in Vershbow's Twitter photos read, "One shot to lose weight," while another offered similar text, "A weekly shot to lose weight."
Turner adding her own commentary, writing, "WTF."
Ozempic maker Novo Nordisk previously told E! News that the drug is not FDA-approved for chronic weight management.
"While we recognize that some healthcare providers may be prescribing Ozempic for patients whose goal is to lose weight, Novo Nordisk does not promote, suggest, or encourage off-label use of our medicines and is committed to fully complying with all applicable U.S. laws and regulations in the promotion of our products," the Danish pharmaceutical company said in a statement. "We trust that healthcare providers are evaluating a patient's individual needs and determining which medicine is right for that particular patient."
Ozempic is no laughing matter for the comedian. Handler revealed her "anti-aging doctor" prescribed the medication without her realizing what the drug was.
"I didn't even know I was on it," she said during the Jan. 25, 2023 episode of Call Her Daddy. "She said, 'If you ever want to drop five pounds, this is good.'"
But while she tried the drug, Handler noted that she didn't like how it made her feel.
"I came back from a vacation and I injected myself with it," she recalled. "I went to lunch with a girlfriend a few days later, and she was like, 'I'm not really eating anything. I'm so nauseous, I'm on Ozempic.' And I was like, 'I'm kind of nauseous too.' But I had just come back from Spain and was jet-lagged."
Ultimately, Handler stopped using the drug because it wasn't medically necessary for her, adding that she gave away the remaining doses to friends.
"I've injected about four or five of my friends with Ozempic, because I realized I didn't want to use it because it was silly," she said. "It's for heavy people. I have people coming over to my house, and I'm like, 'OK, I can see you at 1, I can see you at 2.'"
Khloe Kardashian clapped back when commenters on Instagram speculated that she was taking Ozempic.
"Let's not discredit my years of working out," Kardashian wrote on a January 2023 post. "I get up 5 days a week at 6am to train. Please stop with your assumptions. I guess new year still means mean people."
In addition to embracing the weight-loss drug, Dubrow actually revealed in January 2023 he temporarily used Mounjaro to learn how it affects the body.
"I thought it was amazing," the Botched star shared. "I didn't have that much weight to lose. But I wanted to try it because so many of my patients were on it and I wanted to see what it was like when you're not diabetic and you only have 10 to 15 pounds to lose."
Although Dr. Dubrow didn't disclose how much weight he lost or how long he took the medication for, he confirmed he's no longer using it.
"I thought, 'You know what, I kind of want to get my appetite back,'" he explained the reason for quitting the medication, noting he also experienced "low-grade nausea."
The Real Housewives of Beverly Hills star got real about claims that she was taking the medication after her followers on social media took notice of her weight loss.
Richards wrote back to one user under a Jan. 5, 2023 snap on Instagram of herself and her girlfriends after a workout, "I am NOT on ozempic." In another response, Richards added, "Never have been."
That wouldn't be the last time the Bravo star shot down the rumors, reiterating that she is "NOT taking" the medication under a Jan. 16, 2023 post on Instagram by Page Six.
After fans questioned whether or not she was taking Ozempic, Jessica set the record straight.
"Oh Lord," she told Bustle in an interview published July 6, 2023. "I mean, it is not [Ozempic], it's willpower. I'm like, do people want me to be drinking again? Because that's when I was heavier. Or they want me to be having another baby? My body can't do it."
Nassif echoed his Botched costar in giving the drug two thumbs up.
"Just like he's telling everyone, no Ozempic-shaming," Nassif exclusively told E! News in February 2024. "I'm OK with it. I'm OK with Terry and—actually a lot of my friends I saw this last weekend—they all look incredible. Health-wise, they felt better, their blood sugars came down, their blood pressure came down. All of this can hopefully help with longevity, you just have to do it the right way."
In fact, the famed plastic surgeon said taking Ozempic potentially has other benefits outside of weight management."We're looking into Ozempic more also as an anti-aging treatment for the future," Nassif explained. "So, there's going to hopefully be some good things the more we learn about all these semaglutides and the different products.
A version of this story was first published on Saturday, June 17, 2023 at 3 a.m. PT.
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